Tagged * Nature Biological Sciences Research™

Repeated ER–endosome contacts promote endosome translocation and neurite outgrowth

By Camilla Raiborg The main organelles of the secretory and endocytic pathways—the endoplasmic reticulum (ER) and endosomes, respectively—are connected through contact sites whose numbers increase as endosomes mature. One function of such sites is to enable dephosphorylation of the cytosolic tails of endosomal signalling receptors by an ER-associated phosphatase, whereas others serve to Read Full…

Zoology: Here be dragons

By Andrew J. Hamilton Emerging evidence indicates that dragons can no longer be dismissed as creatures of legend and fantasy, and that anthropogenic effects on the world’s climate may inadvertently be paving the way for the resurgence of these beasts. Nature doi: 10.1038/520042a Read Full Article Here For more great articles: Nature Biological Sciences Research

Recoded organisms engineered to depend on synthetic amino acids

Article Abstract: Genetically modified organisms (GMOs) are increasingly used in research and industrial systems to produce high-value pharmaceuticals, fuels and chemicals. Genetic isolation and intrinsic biocontainment would provide essential biosafety measures to secure these closed systems and enable safe applications of GMOs in open systems, which include bioremediation and probiotics. Although safeguards have been designed…

Common genetic variants influence human subcortical brain structures

Article Abstract: The highly complex structure of the human brain is strongly shaped by genetic influences. Subcortical brain regions form circuits with cortical areas to coordinate movement, learning, memory and motivation, and altered circuits can lead to abnormal behaviour and disease. To investigate how common genetic variants affect the structure of these brain regions, here…

Emotional learning selectively and retroactively strengthens memories for related events

Article Abstract: Neurobiological models of long-term memory propose a mechanism by which initially weak memories are strengthened through subsequent activation that engages common neural pathways minutes to hours later. This synaptic tag-and-capture model has been hypothesized to explain how inconsequential information is selectively consolidated following salient experiences. Behavioural evidence for tag-and-capture is provided by rodent…

Biocontainment of genetically modified organisms by synthetic protein design

Article Abstract: Genetically modified organisms (GMOs) are increasingly deployed at large scales and in open environments. Genetic biocontainment strategies are needed to prevent unintended proliferation of GMOs in natural ecosystems. Existing biocontainment methods are insufficient because they impose evolutionary pressure on the organism to eject the safeguard by spontaneous mutagenesis or horizontal gene transfer, or…

Apico-basal forces exerted by apoptotic cells drive epithelium folding

Article Abstract: Epithelium folding is a basic morphogenetic event that is essential in transforming simple two-dimensional epithelial sheets into three-dimensional structures in both vertebrates and invertebrates. Folding has been shown to rely on apical constriction. The resulting cell-shape changes depend either on adherens junction basal shift or on a redistribution of myosin II, which could…

Structure of the key species in the enzymatic oxidation of methane to methanol

Article Abstract: Methane monooxygenase (MMO) catalyses the O2-dependent conversion of methane to methanol in methanotrophic bacteria, thereby preventing the atmospheric egress of approximately one billion tons of this potent greenhouse gas annually. The key reaction cycle intermediate of the soluble form of MMO (sMMO) is termed compound Q (Q). Q contains a unique dinuclear FeIV…

Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation

Article Abstract: DNA methylation is an epigenetic modification associated with transcriptional repression of promoters and is essential for mammalian development. Establishment of DNA methylation is mediated by the de novo DNA methyltransferases DNMT3A and DNMT3B, whereas DNMT1 ensures maintenance of methylation through replication. Absence of these enzymes is lethal, and somatic mutations in these genes…

Cell biology: Death drags down the neighbourhood

Article Abstract: An analysis of dying cells reveals that they play an active part in modifying tissue shape by pulling on neighbouring cells. This induces neighbouring cells to contract at their apices, which results in tissue folding. from Nature Biological Sciences Research Click Here To Read Full Article Visit Nature Biological Sciences Research for more…

© 2014 JustCookingNews.com Site designed and maintained by Red Rocks Consultants, LLC