Tagged * Nature Genetics™

Common variants in ACYP2 influence susceptibility to cisplatin-induced hearing loss

Article Abstract: Jun Yang, Clinton Stewart and colleagues report the results of a genome-wide association study of cisplatin-induced ototoxicity among children undergoing treatment for brain tumors. They identify common variants in ACYP2 strongly associated with cisplatin-induced hearing loss and ototoxicity severity. from Nature Genetics – AOP – nature.com science feeds Click Here To Read Full…

Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage

Article Abstract: Thierry Wirth, Philip Supply, Stefan Niemann and colleagues analyze 4,987 Mycobacterium tuberculosis strains of the Beijing lineage isolated from 99 countries. They report whole-genome sequencing of 110 representative strains, characterize global population structure and reconstruct the evolutionary history of this lineage. from Nature Genetics – AOP – nature.com science feeds Click Here To…

Genetic architecture of artemisinin-resistant Plasmodium falciparum

Article Abstract: Dominic Kwiatkowski and colleagues report a large multicenter genome-wide association study of Plasmodium falciparum resistance to artemisinin. They identify markers of a genetic background on which kelch13 mutations conferring artemisinin resistance are likely to emerge. from Nature Genetics – AOP – nature.com science feeds Click Here To Read Full Article Visit Nature Genetics…

The landscape of long noncoding RNAs in the human transcriptome

Article Abstract: Arul Chinnaiyan and colleagues report the curation of 7,256 RNA sequencing libraries from tumors, normal tissues and cell lines. They find 58,648 lncRNAs, of which 79% are previously unnannotated. from Nature Genetics – AOP – nature.com science feeds Click Here To Read Full Article Visit Nature Genetics – AOP – nature.com science feeds…

Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism

Article Abstract: Ding Ma, Hui Wang and Xun Xu report a genome-wide map of HPV integration sites in cervical cancer samples and cell lines. In addition to discovering new integration hot spots, the authors identify microhomology-mediated DNA repair as a likely mechanism by which HPV integrates into the human genome. from Nature Genetics – AOP…

Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy

Article Abstract: Akiko Shimamura and colleagues report the identification of dominant-negative germline variants in ETV6 that cause thrombocytopenia and hematologic malignancies in affected members from three families. All three mutations alter conserved amino acids in the transcriptional repressor encoded by ETV6 and affect its DNA binding. from Nature Genetics – AOP – nature.com science feeds…

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