By Juliane I. Beier et al. by Juliane I. Beier, Jenny D. Jokinen, Gretchen E. Holz, Patrick S. Whang, Amah M. Martin, Nikole L. Warner, Gavin E. Arteel, Igor S. Lukashevich Viral hemorrhagic fevers (VHFs) encompass a group of diseases with cardinal symptoms of fever, hemorrhage, and shock. The liver is a critical mediator of…
By Zhi-Hao Shi et al. by Zhi-Hao Shi, Cheng Zhang, Xiao-Feng Xu, Jun Zhu, Que Zhou, Li-Juan Ma, Jin Niu, Zhong-Nan Yang Callose synthesis is critical for the formation of the pollen wall pattern. CalS5 is thought to be the major synthethase for the callose wall. In the Arabidopsis anther, ARF17 regulates the expression of…
By Zoltán Spiró et al. by Zoltán Spiró, Pierre Gönczy The early C. elegans embryo is an attractive model system to investigate fundamental developmental processes. With the exception of mex-3 mRNA, maternally contributed mRNAs are thought to be distributed uniformly in the one-cell embryo. Here, we report and characterize the striking distribution of the mRNA…
By Ying Sun et al. by Ying Sun, Jane Florer, Christopher N. Mayhew, Zhanfeng Jia, Zhiying Zhao, Kui Xu, Huimin Ran, Benjamin Liou, Wujuan Zhang, Kenneth D. R. Setchell, Jianguo Gu, Gregory A. Grabowski Gaucher disease (GD) is caused by insufficient activity of acid β-glucosidase (GCase) resulting from mutations in GBA1. To understand the pathogenesis…
By Zhongheng Zhang et al. by Zhongheng Zhang, Lin Chen, Hongying Ni Background and Objective The effect of antipyretic therapy on mortality in patients with sepsis remains undetermined. The present study aimed to investigate the role of antipyretic therapy in ICU patients with sepsis by using a large clinical database. Methods The multiparameter intelligent monitoring…
By Su Yon Jung et al. by Su Yon Jung, Mara Z. Vitolins, Jenifer Fenton, Alexis C. Frazier-Wood, Stephen D. Hursting, Shine Chang Purpose Risk factors for obesity and weight gain are typically evaluated individually while “adjusting for” the influence of other confounding factors, and few studies, if any, have created risk profiles by clustering…
By Katarina Novovic et al. by Katarina Novovic, Sanja Mihajlovic, Zorica Vasiljevic, Brankica Filipic, Jelena Begovic, Branko Jovcic Carbapenem-resistant A. baumannii present a significant therapeutic challenge for the treatment of nosocomial infections in many European countries. Although it is known that the gradient of A. baumannii prevalence increases from northern to southern Europe, this study…
By Pedro Giovâni da Silva et al. by Pedro Giovâni da Silva, Malva Isabel Medina Hernández Community structure is driven by mechanisms linked to environmental, spatial and temporal processes, which have been successfully addressed using metacommunity framework. The relative importance of processes shaping community structure can be identified using several different approaches. Two approaches that…
By Ezhilarasi Chendamarai et al. by Ezhilarasi Chendamarai, Saravanan Ganesan, Ansu Abu Alex, Vandana Kamath, Sukesh C. Nair, Arun Jose Nellickal, Nancy Beryl Janet, Vivi Srivastava, Kavitha M. Lakshmi, Auro Viswabandya, Aby Abraham, Mohammed Aiyaz, Nandita Mullapudi, Raja Mugasimangalam, Rose Ann Padua, Christine Chomienne, Mammen Chandy, Alok Srivastava, Biju George, Poonkuzhali Balasubramanian, Vikram Mathews There…
By Yufeng Zhai et al. by Yufeng Zhai, Lihua Ao, Joseph C. Cleveland, Qingchun Zeng, T. Brett Reece, David A. Fullerton, Xianzhong Meng The signaling mechanism that mediates inflammatory responses in remote non-ischemic myocardium following regional ischemia/reperfusion (I/R) remains incompletely understood. Myocardial Toll-like receptor 4 (TLR4) can be activated by multiple proteins released from injured…