Tagged * PLOS™

Novel Mechanism of Arenavirus-Induced Liver Pathology

By Juliane I. Beier et al. by Juliane I. Beier, Jenny D. Jokinen, Gretchen E. Holz, Patrick S. Whang, Amah M. Martin, Nikole L. Warner, Gavin E. Arteel, Igor S. Lukashevich Viral hemorrhagic fevers (VHFs) encompass a group of diseases with cardinal symptoms of fever, hemorrhage, and shock. The liver is a critical mediator of…

Polarity-Dependent Asymmetric Distribution and MEX-5/6–Mediated Translational Activation of the Era-1 mRNA in C. elegans Embryos

By Zoltán Spiró et al. by Zoltán Spiró, Pierre Gönczy The early C. elegans embryo is an attractive model system to investigate fundamental developmental processes. With the exception of mex-3 mRNA, maternally contributed mRNAs are thought to be distributed uniformly in the one-cell embryo. Here, we report and characterize the striking distribution of the mRNA…

Properties of Neurons Derived from Induced Pluripotent Stem Cells of Gaucher Disease Type 2 Patient Fibroblasts: Potential Role in Neuropathology

By Ying Sun et al. by Ying Sun, Jane Florer, Christopher N. Mayhew, Zhanfeng Jia, Zhiying Zhao, Kui Xu, Huimin Ran, Benjamin Liou, Wujuan Zhang, Kenneth D. R. Setchell, Jianguo Gu, Gregory A. Grabowski Gaucher disease (GD) is caused by insufficient activity of acid β-glucosidase (GCase) resulting from mutations in GBA1. To understand the pathogenesis…

Carbapenem-Resistant Acinetobacter baumannii from Serbia: Revision of CarO Classification

By Katarina Novovic et al. by Katarina Novovic, Sanja Mihajlovic, Zorica Vasiljevic, Brankica Filipic, Jelena Begovic, Branko Jovcic Carbapenem-resistant A. baumannii present a significant therapeutic challenge for the treatment of nosocomial infections in many European countries. Although it is known that the gradient of A. baumannii prevalence increases from northern to southern Europe, this study…

Scale-Dependence of Processes Structuring Dung Beetle Metacommunities Using Functional Diversity and Community Deconstruction Approaches

By Pedro Giovâni da Silva et al. by Pedro Giovâni da Silva, Malva Isabel Medina Hernández Community structure is driven by mechanisms linked to environmental, spatial and temporal processes, which have been successfully addressed using metacommunity framework. The relative importance of processes shaping community structure can be identified using several different approaches. Two approaches that…

Comparison of Newly Diagnosed and Relapsed Patients with Acute Promyelocytic Leukemia Treated with Arsenic Trioxide: Insight into Mechanisms of Resistance

By Ezhilarasi Chendamarai et al. by Ezhilarasi Chendamarai, Saravanan Ganesan, Ansu Abu Alex, Vandana Kamath, Sukesh C. Nair, Arun Jose Nellickal, Nancy Beryl Janet, Vivi Srivastava, Kavitha M. Lakshmi, Auro Viswabandya, Aby Abraham, Mohammed Aiyaz, Nandita Mullapudi, Raja Mugasimangalam, Rose Ann Padua, Christine Chomienne, Mammen Chandy, Alok Srivastava, Biju George, Poonkuzhali Balasubramanian, Vikram Mathews There…

Toll-like Receptor 4 Mediates the Inflammatory Responses and Matrix Protein Remodeling in Remote Non-Ischemic Myocardium in a Mouse Model of Myocardial Ischemia and Reperfusion

By Yufeng Zhai et al. by Yufeng Zhai, Lihua Ao, Joseph C. Cleveland, Qingchun Zeng, T. Brett Reece, David A. Fullerton, Xianzhong Meng The signaling mechanism that mediates inflammatory responses in remote non-ischemic myocardium following regional ischemia/reperfusion (I/R) remains incompletely understood. Myocardial Toll-like receptor 4 (TLR4) can be activated by multiple proteins released from injured…

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